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Necroptosis can also be materialized as a result of activation of the signaling pathways, due to DNA damage, which leads to the release of apoptosis-related factors from the mitochondrial intermembrane space, followed by the activation of the DNA damage–related enzyme poly(ADP-ribose) polymerase (PARP) [213]

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J Biol Chem (1997) 272(46):28875–81